Everest base camp (˜5180 m)." ĪMS scale: Lake Louise Consensus Symptoms score (LLS) + AMS‐C ScoreĤ0 participants enrolled (healthy lowlanders, non‐smoking). Quote: "supplementation was enforced for 3 weeks at sea level and during a 10‐day ascent to Mt. Unclear impact of administration of intervention during the ascent (additional to prophylaxis) Patient‐important outcomes, such as adverse events, were not reported Quote "all subjects successfully completed the study." () Insufficient information to score this item as low or high risk of bias Quote: "the placebo group ingested four capsules of identical external appearance, taste, and smell that each contained an equal quantity of plant cellulose extract." ()īlinding of outcome assessment (detection bias) Quote ".an investigator who was unaware of the aims of the study and unrelates to data collection or analysis." (page 23)īlinding of participants and personnel (performance bias) Quote ".an investigator who was unaware of the aims of the study and unrelates to data collection or analysis.". Quote ".a computerized pseudo‐random number generator" (page 23). Random sequence generation (selection bias) Role of sponsor: design of the antioxidant/placebo capsules.ĭeclared conflicts of interest: not reported Outcomes were not pre‐specified as primary or secondary Placebo group (control): 4 capsules of identical external appearance, taste and smell, each contained an equal quantity of plant cellulose extract, per 3 weeks at sea level and 10 days until the first morning following arrival at 5180 m. None of the participants randomized were excluded no participants were lost at follow‐upĪntioxidant group (intervention): L‐ascorbic acid 250 mg, dl‐alpha‐tocopherol acetate 100 UI, alpha‐lipoic acid 150 mg, 4 vegetable–based capsules per 3 weeks at sea level and 10 days until the first morning following arrival at 5180 m AMS scale: Lake Louise Consensus scoring systemġ8 participants enrolled (physically active and apparently healthy Caucasian individuals) individuals were all permanent lowland residents with limited Himalayan mountaineering experience.
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